High Quality and High Purity Powder Toremifen Citrate CAS 89778-27-8 *1 CAS NO.89778-27-8

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Min.Order: 1 Kilogram
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Available Specifications:
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Product Details

Keywords

89778-27-8
High purity
Toremifene Citrate

Quick Details

ProName: High Quality and High Purity Powder T...
CasNo: 89778-27-8
Molecular Formula: C24H32O4S
Appearance: White powder
Application: health
DeliveryTime: 3
PackAge: Drum
Port: SHANGHAI
ProductionCapacity: 3000 Kilogram/Day
Purity: 99.5%
Storage: Dry storage
Transportation: air transport /Ocean Shipping
LimitNum: 1 Kilogram
Related Substances: 《0.1%
Residue on Ignition: 《0.1%
Heavy Metal: 《0.1%
Valid Period: 《0.1%
monthly production: 20kg
Customs code: 29000000

Superiority

Our Advantage:

.high quality

.high purity

.best price

.best service

.professional manufacturer

.loyal and honest supplier

.fast response to customer immediately

1.We have stock so we can delivery quickly at the very day when receive the payment.

2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.

3.High quality guarenteed, once any problem is found, the package would be reshipped for you

4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.

5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.

Superiority

1. rich experience.

our company is a professional production leading factory in china in pharmaceutical area of many years, our products have exported to germany, spain, uk, usa, australia, middle east, and so on other country, and we have got very good feedback from our customers, we had established long friendly relations of cooperation. high quality, best price!

2. great quality, purity and favourable.

all products are produced under gmp conditions according to standard operation procedure(sop), not from little underground labs or black markets, so the quality is guaranteed.

good quality is one of our secret success, welcome order the samples, moq just 10 grams.

3. safe and fast delivery.

we have warehouse in australia, canada and england, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse! so we can delivery quickly at the very day when receive the payment. and we offer melting powder into liquid service.

our logistics department delivery parcel within 12 hours after confirming payment.

99% customs clearance rate.we have rich experience in shipping parcel to usa, australia, uk,canada, brazil, russia, germany, poland, mexico, etc.

4. good after-sales service.

excllent customer service. any question or doubt would be solved immediately.

5. discreet packing methods. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.

6. injectable steroid. we offer melting powder into liquid service.and ship the liquid in special bottles.

Details

With the high quality products and service, DMK aims to solve the customers' purchasing troubles and ensure the high efficiency and stability of the customers' supply chain.The company provides small batches of goods for customers' diversified needs, and reduces the trial risks and costs.

Name: Toremifene Citrate

Synonyms: Toremifene Citrate;FC 1157A; Fareston; NK 622; NSC 613680

CAS: 89778-27-8

Molecular Formula: C26H28ClNO. C6H8O7

Molecular Weight: 598.09

Melting Point: 158-164 º C

Boiling Point: 535.1 º C at 760 mmHg

Density: 1.045g/cm3

Refractive index: 1, 416-1, 418

Appearance: White or almost white powder

Assay:99%

Standard:USP

Export Markets:Global

Package: 1kg/foil bag; 25kg/drum

Delivery time: Within 18 hours upon receipt of payment

Delivery: EMS, DHL, TNT, FedEx, UPS

Usage:Originally developed to fight breast cancer, bodybuilders have used Fareston to successfully fight gynocomastia caused when testosterone converts to estrogen in the body and men grow breasts. This substance can be used for little else and other similar compounds, such as Nolvadex or Clomid, are much more effective in post-cycle-therapy. Other drugs in same class: Tamoxifen citrate..

1. Quick Detail:

1. CAS No:89778-27-8

2. Molecular Formula: C26H28ClNO.C6H8O7

3. Assay: 97.0%~103.0%

4. Appearance: White crystalline powder.

5. Usage:Originally developed to fight breast cancer, bodybuilders have used Fareston to successfully fight gynocomastia caused when converts to estrogen in the body and men grow breasts. This substance can be used for little else and other similar compounds, such as Nolvade or Clomid, are much more effective in post-cycle-therapy.

2. Description:

Toremifen(e) citrate, chemical name Z-2-[4-(4-chloro-1, 2-diphenyl)-1-butenyl]phenoxy]-N, N -Dimethyl ethylamine monophthalate, a new generation of anti-estrogen antitumor drug developed by Farmos in Finland in 1979. It is a derivative of non-steroidal tristyryl. It was first developed in Finland in 1988. The listed non-steroidal anti-estrogen antitumor drugs are mainly used for the treatment of breast cancer.

is a member of a category, family, and class of drugs that are known as SERMs (Selective Estrogen Receptor Modulators). SERMs fall under an even broader category of drugs that are known as anti-estrogens, and the cousin family of SERMs (that also fall under anti-estrogens) are aromatase inhibitors, commonly abbreviated as AIs. SERMs include compounds such as Nolvade and Clomid (Clomiphene Citrate). Aromatase inhibitors (AIs) include compounds such as Arimide ) Aromasin, (Femara). Although the two fall under the category of anti-estrogens, they are both sub-categories that branch off into their own families, as SERMs and AIs differ greatly in their mechanism of action within the human body concerning how they control or block Estrogen. There has been much misunderstanding and misconception in previous decades as to what each of these do, and this should always be first clarified to the reader before describing Toremifen.

3. Applications:

Toremifen citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifen citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

It has already been covered that Toremifen is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifen pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifen, real Estrogen cannot perform their jobs there.

Toremifen does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of so that it can utilize aromatization to restore these levels.

Toremifen is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifen will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an cycle, such as improving and shifting cholesterol levels into a more favorable range.

4. Specification:

COA:

Test items Quality requirements Results

Description White or like white crystalline powder White crystalline powder

Solubility Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether

Melting point 159~163ºC 159.0~160.5ºC

Identification

(a)Positive reaction Must comply Complies

(b)Positive reaction Must comply Complies

(c) UV There is the strongest absorption at the wavelength of 234~238nm and 275~278nm. There is the strongest absorption at the wavelength of 236.8nm and 276.2nm.

(d) IR There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 . There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 .

Purity 99%

(a) Relative substances

E-isomer ≤0.5% 0.001%

Total relative substances ≤1.0% 01%

(b)Heavy metals ≤10ppm <10ppm

Loss on drying ≤1.0% 0.1%

≤0.089% 0.0002%

Ethanol ≤0.5% 0

Acetone ≤0.5% 0.21%

≤0.072% 0.0001%

Chlorobenzen ≤0.036% 0

Benzene ≤0.0002% 0

Residue on ignition ≤0.1% 0.04%

Assay ≥98.5% (Calculated by C26H28ClNO .C6H8O7) 99.7%

Conclusion: The results comply with the requirements of the export standard.

Toremifen(e) citrate Pharmacological effects:

The combination of toremifen(e) citrate with estrogen receptors can produce estrogen-like or anti-estrogen effects, or both, depending on the length of treatment, animal species, sex, and target organ. In general, non-steroidal tristyryl derivatives act primarily as anti-estrogen in humans and rats and as estrogen-like effects in mice. The use of toremifen(e) in postmenopausal breast cancer patients induced a moderate decrease in serum total cholesterol and low density lipoprotein (LDL). Toremifen(e) citrate and estrogen competitively bind to estrogen receptors in cytoplasm of breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation in cancer cells. A large dose of toremifen(e) citrate was used in some experimental tumors, demonstrating the non-estrogen-dependent antitumor effects of toremifen(e) citrate. The anti-breast cancer effect of toremifen(e) citrate is mainly an anti-estrogen effect, and may also have other anti-cancer mechanisms (change in tumor gene expression, secrete growth factors, induce apoptosis, and affect cell cycle dynamics).

Our Advantage:

1.We have stock so we can delivery quickly at the very day when receive the payment.

2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.

3.High quality guarenteed, once any problem is found, the package would be reshipped for you

4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.

5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

FAQ

1.How about parcel delivery success rate

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time

Normally, our min.order quantity is 10g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship by TNT or FedEx.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

FAQ

1.How about parcel delivery success rate

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time

Normally, our min.order quantity is 10g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship b

QAF

Q1: Can i get some samples

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or MoneyGram or Escrow

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:Is there a discount

A:Different quantity has different discount.

Q5: How do you treat quality complaint

A:First of all, our quality control will reduce the quality problem to near zero. If there is a

real quality problem caused by us, we will send you free goods for replacement or refund your loss.

4.QAF