China (Mainland)
Pharmaceutical Intermediates PRL-8-53 Purity 99% with Best Wholesale Price CAS NO.51352-87-5
- FOB Price: USD: 0.95-1.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: T/T,MoneyGram
- Available Specifications:
99(1-10)Gram99(10-100)Gram
- Product Details
Keywords
- PRL-8-53
- PRL-8-53 Powder
- Nootropics
Quick Details
- ProName: Pharmaceutical Intermediates PRL-8-53 ...
- CasNo: 51352-87-5
- Molecular Formula: C18H22ClNO2
- Appearance: Powder
- Application: For Chemcial Research Only
- DeliveryTime: 7DAYS
- PackAge: Packing according to customer's requir...
- Port: SHANGHAI
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99%
- Storage: Keep Dry
- Transportation: Shipping by EMS,Fedex and DHL ect.
- LimitNum: 1 Gram
- Related Substances: 0.01
- Residue on Ignition: 0.01
- Heavy Metal: 0.01
- Valid Period: 24m
- CAS:: 51352-87-5
- MF:: C18H22ClNO2
- MW:: 319.82578
Superiority
Wuhan Demeikai Biotechnology Co., Ltd is a legitimate companies which registration in the Trade and Industry Bureau.Main business:Research and development, production and sales of Steriods,Peptides,raw materials and intermediates.
The company has a legitimate import and export qualifications, and in the State Ministry of Commerce for the record registration, registration number 03027567.
We are the forefront of Chinese for the production and sales of raw materials business, the company is located in Wuhan University high-tech business incubator, relying on the "innovation" wave of national support program and having a reputation for goverment supporting plan.Owning a large number of outstanding scientific research talents and equipped with advanced production equipment and efficiently sophisticated detection equipment, setting up a strict and scientific quality management system, and continuously committed to technological innovation, product innovation and management innovation.
Company purpose:Quality is the foundation of development,always maintain a competitive price.
Hope to achieve mutually beneficial and win-win goal with our customers.
Details
Product Name: PRL-8-53
Synonyms: PRL-8053;PRL-8-53;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
CAS: 51352-87-5
MF: C18H22ClNO2
MW: 319.82578
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
Description
PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%.
HOW IT WORKS
PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.
Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
Dosage
The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.
SIDE EFFECTS
No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but evidence is very limited because no comprehensive toxicity studies have been completed.
Our superiority
1. We has passed the ISO9001: 2000 (quality management system certification) ISO14001: 2004 (environmental management system certification), OHSMS (occupational health and safety system certification) three system certification, won the "Attaches great importance to contract, keep promise" and won Hubei Province Civilized units and many other honors.
2.The company's large-scale, solid technical foundation, adequate supply,so that we can meet the different needs of various customers.
3. Professional sales team to meet the various needs of customers, customers timely answers to various questions,achieve good communication,ensure good after-sales service and solve your worries.
4.Improve the logistics system to ensure that customers will konw the movements of goods in the first time after the shipment.
5.To provide third-party product testing reports, integrity management.
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How to order
1. Let me know the products with quantity you are interesting and your requirement, you will get the best offer.
2. After we confirm all the details about the order, Products will send out within 24 hours after we received your payment(MoneyGram,，T/T is accepted).
3. Tracking No. will send to you within 2-3days.After 7days you will received your package.
4. We will take care of your order till parcel to your door, and expecting for your further feedback, 24 hours on line for after-sale service.
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