High Quality and High Purity Imatinib 152459-95-5 CAS NO.152459-95-5

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Product Details

Keywords

152459-95-5
High purity
Imatinib

Quick Details

ProName: High Quality and High Purity Imatinib ...
CasNo: 152459-95-5
Molecular Formula: C29H31N7O
Appearance: White powder
Application: health
DeliveryTime: 3
PackAge: Drum
Port: SHANGHAI
ProductionCapacity: 3000 Kilogram/Day
Purity: 99.5%
Storage: Dry storage
Transportation: air transport /Ocean Shipping
LimitNum: 1 Kilogram
Related Substances: 《0.1%
Residue on Ignition: 《0.1%
Heavy Metal: 《0.1%
Valid Period: 《0.1%
monthly production: 20kg
Customs code: 29000000

Superiority

Our Advantage:

.high quality

.high purity

.best price

.best service

.professional manufacturer

.loyal and honest supplier

.fast response to customer immediately

1.We have stock so we can delivery quickly at the very day when receive the payment.

2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.

3.High quality guarenteed, once any problem is found, the package would be reshipped for you

4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.

5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.

Superiority

1. rich experience.

our company is a professional production leading factory in china in pharmaceutical area of many years, our products have exported to germany, spain, uk, usa, australia, middle east, and so on other country, and we have got very good feedback from our customers, we had established long friendly relations of cooperation. high quality, best price!

2. great quality, purity and favourable.

all products are produced under gmp conditions according to standard operation procedure(sop), not from little underground labs or black markets, so the quality is guaranteed.

good quality is one of our secret success, welcome order the samples, moq just 10 grams.

3. safe and fast delivery.

we have warehouse in australia, canada and england, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse! so we can delivery quickly at the very day when receive the payment. and we offer melting powder into liquid service.

our logistics department delivery parcel within 12 hours after confirming payment.

99% customs clearance rate.we have rich experience in shipping parcel to usa, australia, uk,canada, brazil, russia, germany, poland, mexico, etc.

4. good after-sales service.

excllent customer service. any question or doubt would be solved immediately.

5. discreet packing methods. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.

6. injectable steroid. we offer melting powder into liquid service.and ship the liquid in special bottles.

Details

With the high quality products and service, DMK aims to solve the customers' purchasing troubles and ensure the high efficiency and stability of the customers' supply chain.The company provides small batches of goods for customers' diversified needs, and reduces the trial risks and costs.

a multi-target inhibitor

Imatinib Basic Info.

Synonyms:IMA-3;IMATINIB;IMATINIB-D3;AKOS 91378;IMATINIB 99+%;Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-;Imatinib Mesilate;4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide methanesulfonate

CAS:152459-95-5

MF:C29H31N7O

MW:493.6

Chemical Properties:Orange Solid

Usage:Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib also known as Gleevec, Glivec, CGP-57148B, STI-571 & Imatinib

antineoplastic

atypical antipsychotic

Imatinib impurity

Description of Imatinib

1.Imatinib (INN), marketed by Novartis as Gleevec (Canada, South Africa and the USA) or Glivec (Australia, Europe and Latin America), investigational name STI-571, is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).

2.Imatinib kills cancer cells by turning off tyrosine kinases. In order to survive, cells need signaling through proteins (signal cascade) to keep them alive. Some of the proteins in this cascade use a phosphate group as an "on" switch. This phosphate group is added by a tyrosine kinase enzyme. In healthy cells, these tyrosine kinase enzymes are turned on and off as needed. In Ph-positive CML cells, one tyrosine kinase enzyme, BCR-Abl, is stuck on the "on" position, and keeps adding phosphate groups. Imatinib blocks this BCR-Abl enzyme, and stops it from adding phosphate groups. As a result, these cells stop growing, and even die by a process of cell death (apoptosis). Because the BCR-Abl tyrosine kinase enzyme exists only in cancer cells and not in healthy cells, imatinib works as a form of targeted therapy-only cancer cells are killed through the drug's action. In this regard, imatinib was one of the first cancer therapies to show the potential for such targeted action, and is often cited as a paradigm for research in cancer therapeutics.

3.Due in large part to the development of Gleevec and related drugs having a similar mechanism of action, the five year survival rate for people with chronic myeloid leukemia nearly doubled from 31% in 1993 (before Gleevec's 2001 FDA approval) to 59% for those diagnosed between 2003 and 2009.Compared to older drugs imatinib has a relatively benign side effect profile, allowing many patients to live a normal lifestyle. Median survival for imatinib-treated people with gastrointestinal stromal tumors (GIST) is nearly 5 years compared to 9 to 20 months in the pre-imatinib-era.

Medical uses

Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies.

Paroxetine

Sertraline

Fluvoxamine maleate,

Citalopram hydrobromide,

Duloxetine hydrochloride,

Venlafaxine hydrochloride

Duloxetine

Bupropion

Trazodone

Nefazodone

Mirtazapine

Moclobemide

Escitalopram

Gabapentin hydrochloride

Our Advantage:

1.We have stock so we can delivery quickly at the very day when receive the payment.

2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.

3.High quality guarenteed, once any problem is found, the package would be reshipped for you

4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.

5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

FAQ

1.How about parcel delivery success rate

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time

Normally, our min.order quantity is 10g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship by TNT or FedEx.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express

FAQ

1.How about parcel delivery success rate

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time

Normally, our min.order quantity is 10g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship b

QAF

Q1: Can i get some samples

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or MoneyGram or Escrow

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:Is there a discount

A:Different quantity has different discount.

Q5: How do you treat quality complaint

A:First of all, our quality control will reduce the quality problem to near zero. If there is a

real quality problem caused by us, we will send you free goods for replacement or refund your loss.

4.QAF

Q1: Can i get some samples

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or MoneyGram or Escrow

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:Is there a discount

A:Different quantity has different discount.

Q5: How do you treat quality complaint

A:First of all, our quality control will reduce the quality problem to near zero. If there is a

real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Product name: CRL-40, 941

Alias: AcetaMide, 2-[[bis(4-fluorophenyl)Methyl]sulfinyl]-N-hydroxy-;2-[bis(4-fluorophenyl)Methyl]sulfinylethanehydroxaMic acid;CRL-40, 941;CRL-40, 941 (Bisflu);2-[[Bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxyacetamide;CRL-40,941;CRL-40, 941, Bisflu

CAS: 90212-80-9

MF: 15H13F2NO3S

MW: 325.3304264

CRL-40, 941 is a white crystalline solid substance that has been described as closely related to both CRL-40, 941. It was developed by the French pharmaceutical company Lafon Laboratories as a new research chemical. CRL-40, 941 is known for its other names CRL-40, 941, CRL-40, 941 and its chemical name 2-{[Bis(4-fluorophenyl)methyl]sulfinyl}-N-hydroxyacetamide

Fluorafinil is a halogenic compound and has been identified as CRL-40, 941 bis(p-fluoro) ring substitute. As a fluorinated derivative, it has been described as more potent than CRL-40, 941

What is CRL-40, 941

CRL-40, 941 is also referred to as CRL-40,941 or fluorafinil. It is a wakefulness-promoting agent that is found in the eugeroic classification of drugs. CRL-40, 941 is closely related to CRL-40, 941. Though it's chemical composition and effects are very similar, it is capable of producing anti-aggressive effects while CRL-40, 941 doesn't have this ability. CRL-40, 941 is the bis(p-fluoro) ring-substituted derivative of CRL-40, 941 .It promotes wakefulness and thought acceleration. It increases cognitive function, motivation, and improves memory as it works on dopamine and histamine neurotransmitters in the brain.

Effects

The drug is reported to have little or no side effects when taken at the correct dose over a short period of time. CRL-40, 941 is ONLY designed and intended for short term use. Long-term use and misuse of the drug can affect our brain in many ways. This medicine blocks the reuptake of dopamine and norepinephrine in the presynaptic cleft immediately upon being released. Long-term use of the drug causes lesions on cerebral blood pathways and brain injury affects the efficiency of neurotransmitter substances in our brain.

Dosage

CRL-40, 941 is 3-4 more potent than CRL-40, 941. New users should start with 30-80 mgs within 14-16 hours daily, and CRL-40, 941 moderate dose is between 30-100 mg per day. The dosage to be increased as the effects are being experienced as the body reacts towards the dose. Dosage should not exceed 200mgs per day.